ea0041gp26 | Adrenal (2) | ECE2016
Creemers Sara G
, Feelders Richard A
, de Jong Frank H
, Franssen Gaston J H
, de Rijke Yolanda B
, van Koetsveld Peter M
, Hofland Leo J
Introduction: The steroidogenesis inhibitors ketoconazole and metyrapone are frequently used for treatment of Cushings syndrome, but can cause side effects. LCI699 is a known 11β-hydroxylase inhibitor, but effects on other steroidogenic enzymes are unknown. We aimed to compare effects of LCI699, ketoconazole, and metyrapone in vitro.Methods: HAC-15 cells, with or without 10 nM ACTH, and three primary human adrenocortical adenoma cultu...